Benedikt M Kessler Selected Research

Fumarate Hydratase (Fumarase)

8/2014	The Succinated Proteome of FH-Mutant Tumours.
3/2013	Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency.
10/2011	Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling.

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Benedikt M Kessler Research Topics

Disease

54	Neoplasms (Cancer) 05/2024 - 10/2002
14	Infections 04/2024 - 12/2008
12	Inflammation (Inflammations) 04/2024 - 09/2013
12	Hypoxia (Hypoxemia) 01/2022 - 03/2009
9	Genomic Instability 01/2019 - 03/2011
7	Carcinogenesis 10/2022 - 10/2011
5	Breast Neoplasms (Breast Cancer) 11/2020 - 01/2017
4	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2024 - 11/2011
4	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 12/2023 - 01/2018
4	Virus Diseases (Viral Diseases) 12/2023 - 02/2004
4	Acute-Phase Reaction 01/2023 - 01/2018
4	Endometriosis 03/2020 - 03/2011
4	Communicable Diseases (Infectious Diseases) 01/2018 - 12/2008
4	Prostatic Neoplasms (Prostate Cancer) 04/2015 - 11/2008
3	Sarcopenia 05/2024 - 08/2007
3	Melanoma (Melanoma, Malignant) 03/2024 - 05/2013
3	Parkinson Disease (Parkinson's Disease) 01/2023 - 01/2016
3	Neoplasm Metastasis (Metastasis) 11/2019 - 11/2008
3	Anemia 01/2018 - 05/2011
3	Disease Progression 01/2018 - 11/2016
3	Rheumatoid Arthritis 12/2017 - 01/2015
3	Malaria 06/2014 - 05/2012
3	Multiple Myeloma 09/2012 - 05/2005
3	Pathologic Processes 06/2011 - 11/2008
2	Alzheimer Disease (Alzheimer's Disease) 05/2024 - 01/2021
2	Bloom Syndrome 01/2024 - 01/2021
2	Fibrosis (Cirrhosis) 08/2023 - 02/2022
2	Osteoarthritis 12/2022 - 12/2017
2	COVID-19 12/2022 - 11/2020
2	Reperfusion Injury 02/2022 - 01/2022
2	Ulcerative Colitis 11/2021 - 04/2016
2	Brain Death (Brain Dead) 09/2021 - 01/2021
2	Pain (Aches) 01/2020 - 01/2018
2	Colorectal Neoplasms (Colorectal Cancer) 11/2019 - 10/2008
2	Chronic Obstructive Pulmonary Disease (COPD) 01/2018 - 01/2015
2	Viremia 11/2016 - 05/2010
2	Hereditary leiomyomatosis and renal cell cancer 08/2014 - 03/2013

Drug/Important Bio-Agent (IBA)

50	Proteins (Proteins, Gene)FDA Link 05/2024 - 08/2007
17	Biomarkers (Surrogate Marker)IBA 12/2023 - 10/2008
17	EnzymesIBA 01/2023 - 03/2004
16	Peptides (Polypeptides)IBA 01/2021 - 06/2007
12	UbiquitinIBA 03/2024 - 06/2010
8	Peptide Hydrolases (Proteases)FDA Link 12/2022 - 10/2002
7	DNA (Deoxyribonucleic Acid)IBA 04/2024 - 03/2011
7	Deubiquitinating EnzymesIBA 03/2024 - 03/2009
6	ProteomeIBA 01/2020 - 03/2009
5	InterferonsIBA 12/2023 - 09/2011
5	Oxygen (Dioxygen)IBA 01/2018 - 03/2009
4	VaccinesIBA 12/2022 - 06/2015
4	Mixed Function Oxygenases (Monooxygenases)IBA 01/2022 - 04/2011
4	Transcription Factors (Transcription Factor)IBA 01/2019 - 03/2009
4	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 01/2010
3	Ubiquitin-Specific ProteasesIBA 01/2023 - 05/2014
3	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 10/2022 - 01/2017
3	Arginine (L-Arginine)FDA Link 11/2021 - 01/2017
3	Histones (Histone)IBA 11/2021 - 08/2010
3	Complement System Proteins (Complement)IBA 09/2021 - 05/2010
3	AntigensIBA 01/2018 - 06/2015
3	EpitopesIBA 01/2018 - 12/2017
3	Phosphotransferases (Kinase)IBA 01/2016 - 03/2009
3	Fumarate Hydratase (Fumarase)IBA 08/2014 - 10/2011
3	OxygenasesIBA 03/2014 - 04/2011
3	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 03/2014 - 07/2011
3	Matrix Metalloproteinase 9 (Gelatinase B)IBA 09/2013 - 11/2008
3	Bortezomib (Velcade)FDA Link 09/2012 - 05/2005
2	Interferon Type IIBA 04/2024 - 01/2018
2	T-Cell Antigen Receptors (T-Cell Receptor)IBA 04/2024 - 01/2017
2	Proteasome Endopeptidase Complex (Proteasome)IBA 03/2024 - 11/2011
2	telomerase RNA (bTR)IBA 01/2024 - 01/2021
2	Cruciform DNA (Holliday Junctions)IBA 01/2024 - 01/2021
2	Fatty Acids (Saturated Fatty Acids)IBA 10/2023 - 01/2018
2	Ligases (Synthetase)IBA 10/2022 - 01/2012
2	dicarboxydine (DCD)IBA 01/2022 - 01/2021
2	CytokinesIBA 11/2021 - 11/2016
2	CitrullineIBA 11/2021 - 01/2015
2	ChromatinIBA 11/2021 - 01/2017
2	IsotopesIBA 01/2021 - 04/2015
2	Carrier Proteins (Binding Protein)IBA 10/2020 - 03/2009
2	Messenger RNA (mRNA)IBA 10/2020 - 08/2007
2	Oxidoreductases (Dehydrogenase)IBA 03/2020 - 01/2020
2	AminesIBA 03/2020 - 01/2020
2	Hemoglobins (Hemoglobin)IBA 01/2020 - 03/2013
2	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 01/2019 - 12/2018
2	C-Reactive ProteinIBA 01/2018 - 01/2017
2	VimentinIBA 12/2017 - 01/2015
2	TenascinIBA 12/2017 - 10/2016
2	Amino Acids FDA Link 01/2017 - 04/2015
2	AsparagineIBA 01/2017 - 03/2011
2	Serine (L-Serine)FDA Link 01/2017 - 04/2015
2	ChemokinesIBA 11/2016 - 11/2008
2	Cyclin B1IBA 11/2016 - 05/2013
2	ubiquitin isopeptidaseIBA 04/2015 - 01/2015
2	Cysteine (L-Cysteine)FDA Link 08/2014 - 10/2011
2	Ketoglutaric Acids (Ketoglutaric Acid)IBA 03/2014 - 04/2011
2	Protease NexinsIBA 09/2013 - 11/2008
2	CollagenIBA 09/2013 - 11/2008

Therapy/Procedure

15	Therapeutics 05/2024 - 09/2005
4	Immunotherapy 04/2024 - 01/2017
2	Drug Therapy (Chemotherapy) 01/2021 - 01/2018
2	Radiotherapy 01/2021 - 01/2018